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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TIMP4
All Species:
12.73
Human Site:
S110
Identified Species:
25.45
UniProt:
Q99727
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99727
NP_003247.1
224
25503
S110
G
V
K
L
E
A
N
S
Q
K
Q
Y
L
L
T
Chimpanzee
Pan troglodytes
XP_516284
224
25530
S110
G
V
K
L
E
A
N
S
Q
K
Q
Y
L
L
T
Rhesus Macaque
Macaca mulatta
Q95KL9
207
23229
R102
Y
F
H
R
S
H
N
R
S
E
E
F
L
I
A
Dog
Lupus familis
XP_538410
211
24134
L103
E
V
N
K
Y
Q
Y
L
L
T
G
R
V
Y
D
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHB3
224
25755
S110
G
V
K
L
E
T
N
S
H
K
Q
Y
L
L
T
Rat
Rattus norvegicus
P81556
224
25704
S110
G
V
K
L
E
T
N
S
Q
K
Q
Y
L
L
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509154
355
40199
X192
I
R
Q
K
X
X
X
X
X
X
X
X
G
M
P
Chicken
Gallus gallus
O42146
220
24294
G106
G
Q
P
L
D
T
G
G
K
K
E
Y
L
I
A
Frog
Xenopus laevis
O73746
214
24437
V100
L
C
G
V
K
L
E
V
N
K
Y
Q
Y
L
I
Zebra Danio
Brachydanio rerio
NP_998461
217
23950
G103
G
V
N
L
E
S
N
G
K
Q
E
Y
L
I
T
Tiger Blowfish
Takifugu rubipres
NP_001033041
219
24565
N105
C
G
V
S
L
Q
A
N
G
K
E
Y
L
I
T
Fruit Fly
Dros. melanogaster
Q9VH14
210
23961
K104
G
I
N
L
D
L
G
K
V
Y
I
V
A
G
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
34.8
46.4
N.A.
88.8
89.7
N.A.
31.2
44.2
46.8
47.7
45.9
21.4
N.A.
N.A.
N.A.
Protein Similarity:
100
99.1
50.8
65.1
N.A.
92.8
93.7
N.A.
43.3
66.9
61.6
64.7
66
41.9
N.A.
N.A.
N.A.
P-Site Identity:
100
100
13.3
6.6
N.A.
86.6
93.3
N.A.
0
33.3
13.3
53.3
26.6
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
40
13.3
N.A.
86.6
93.3
N.A.
13.3
60
26.6
86.6
46.6
26.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
17
9
0
0
0
0
0
9
0
17
% A
% Cys:
9
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
17
0
0
0
0
0
0
0
0
0
9
% D
% Glu:
9
0
0
0
42
0
9
0
0
9
34
0
0
0
0
% E
% Phe:
0
9
0
0
0
0
0
0
0
0
0
9
0
0
0
% F
% Gly:
59
9
9
0
0
0
17
17
9
0
9
0
9
9
0
% G
% His:
0
0
9
0
0
9
0
0
9
0
0
0
0
0
0
% H
% Ile:
9
9
0
0
0
0
0
0
0
0
9
0
0
34
9
% I
% Lys:
0
0
34
17
9
0
0
9
17
59
0
0
0
0
0
% K
% Leu:
9
0
0
59
9
17
0
9
9
0
0
0
67
42
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% M
% Asn:
0
0
25
0
0
0
50
9
9
0
0
0
0
0
0
% N
% Pro:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
9
% P
% Gln:
0
9
9
0
0
17
0
0
25
9
34
9
0
0
0
% Q
% Arg:
0
9
0
9
0
0
0
9
0
0
0
9
0
0
9
% R
% Ser:
0
0
0
9
9
9
0
34
9
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
25
0
0
0
9
0
0
0
0
50
% T
% Val:
0
50
9
9
0
0
0
9
9
0
0
9
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
9
0
9
0
0
9
9
59
9
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _